Bacterial toxin-antitoxin systems targeting translation
نویسندگان
چکیده
منابع مشابه
Bacterial toxin-antitoxin systems targeting translation
Toxin-antitoxin systems (TAS) emerged more than 25 years ago and have since developed as an important field in molecular microbiology. TAS are autoregulated operons coding a stable toxin and an unstable antitoxin found in the plasmids and chromosomes of Bacteria and Archaea. The conditional activation of their toxins interferes with cell growth/viability and, depending on the context, can influ...
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*Correspondence to: Laurence Van Melderen; Email: [email protected] Toxin-antitoxin (TA) systems are composed of two elements: a toxic protein and an antitoxin which is either an RNA (type I and III) or a protein (type II). Type II systems are abundant in bacterial genomes in which theymove via horizontal gene transfer. They are generally composed of two genes organized in an operon, encoding ...
متن کاملBacterial toxin-antitoxin systems
Toxin-antitoxin (TA) systems are composed of two elements: a toxic protein and an antitoxin which is either an RNA (type I and III) or a protein (type II). Type II systems are abundant in bacterial genomes in which they move via horizontal gene transfer. They are generally composed of two genes organized in an operon, encoding a toxin and a labile antitoxin. When carried by mobile genetic eleme...
متن کاملToxin–antitoxin systems
Toxin-antitoxin (TA) systems are small genetic elements composed of a toxin gene and its cognate antitoxin. The toxins of all known TA systems are proteins while the antitoxins are either proteins or non-coding RNAs. Based on the molecular nature of the antitoxin and its mode of interaction with the toxin the TA modules are currently grouped into five classes. In general, the toxin is more stab...
متن کاملBacterial Toxin–Antitoxin Systems: More Than Selfish Entities?
Bacterial toxin-antitoxin (TA) systems are diverse and widespread in the prokaryotic kingdom. They are composed of closely linked genes encoding a stable toxin that can harm the host cell and its cognate labile antitoxin, which protects the host from the toxin's deleterious effect. TA systems are thought to invade bacterial genomes through horizontal gene transfer. Some TA systems might behave ...
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ژورنال
عنوان ژورنال: Journal of Applied Biomedicine
سال: 2010
ISSN: 1214-021X,1214-0287
DOI: 10.2478/v10136-009-0021-9